GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs10935120 | 1 | rs6766818 | chr3:134226159 | CEP63 | chr3:134204575-134293852:+ | 0.29 | 6.27 | 8.12E-10 | Height |
| THCA | cis | rs10935120 | 1 | rs6766897 | chr3:134191303 | ANAPC13 | chr3:134196547-134204865:- | 0.34 | 10.49 | 2.55E-23 | Height |
| THCA | cis | rs10935120 | 1 | rs6766897 | chr3:134191303 | CEP63 | chr3:134204575-134293852:+ | 0.28 | 6.15 | 1.59E-9 | Height |
| THCA | cis | rs6767049 | 1 | rs6767049 | chr3:20220712 | KAT2B | chr3:20081524-20195894:+ | -0.16 | -3.72 | 0.000224 | Temperament (bipolar disorder) |
| THCA | cis | rs9815925 | 1 | rs6767366 | chr3:184753814 | C3orf70 | chr3:184795840-184870802:- | -0.23 | -4.68 | 3.82E-6 | Heschl's gyrus morphology |
| THCA | cis | rs73201462 | 1 | rs67674204 | chr3:127824778 | EEFSEC | chr3:127872313-128127488:+ | -0.25 | -4.42 | 1.23E-5 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs1552244 | 1 | rs6768102 | chr3:10149380 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.38 | 1.48E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6768102 | chr3:10149380 | VHL | chr3:10183319-10193744:+ | -0.17 | -4.08 | 5.24E-5 | Alzheimer's disease |
| THCA | cis | rs9815354 | 1 | rs6768128 | chr3:41865080 | ULK4 | chr3:41288091-42003660:- | 1.04 | 19.41 | 2.7E-62 | Diastolic blood pressure |
| THCA | cis | rs9815354 | 1 | rs6768542 | chr3:41865474 | ULK4 | chr3:41288091-42003660:- | 1.04 | 19.1 | 7.17E-61 | Diastolic blood pressure |
| THCA | cis | rs9815354 | 1 | rs6768563 | chr3:41865541 | ULK4 | chr3:41288091-42003660:- | 1.04 | 19.1 | 7.17E-61 | Diastolic blood pressure |
| THCA | cis | rs11825709 | 1 | rs67689846 | chr11:93660950 | HEPHL1 | chr11:93754378-93847374:+ | 0.5 | 4.26 | 2.42E-5 | Obesity-related traits |
| THCA | cis | rs11825709 | 1 | rs67689846 | chr11:93660950 | PANX1 | chr11:93862094-93915135:+ | 0.35 | 3.46 | 0.000579 | Obesity-related traits |
| THCA | cis | rs12762955 | 1 | rs67696450 | chr10:1090684 | IDI2 | chr10:1064847-1071799:- | -0.24 | -3.46 | 0.000597 | Response to angiotensin II receptor blocker therapy |
| THCA | cis | rs10935120 | 1 | rs6769885 | chr3:134286913 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 12.93 | 5.06E-33 | Height |